Keepass db doesn’t use email 2fa, its just a file you store on your device
I store it on all my devices so if I lose one I still have several others.
I use nextcloud to keep them syncd but you can use any cloud (google drive, icloud, one drive, Dropbox, etc)
I use an email client which saves my password and I don’t need to enter it. But the keepass db can also store your email password for you.
Keepass db syncd on cloud with multiple devices, 2FA using email instead of mobile number.
I sit it behind a traefik reverse proxy, I have a few other services running too, no issues.
Nextcloud AIO (all in one) is a docker compose nextcloud instance that handles all of the optimizations for you. That’s what I use. I host it on a VPS I lease from contabo. Nextcloud is fast enough for me. I don’t need lightning speeds.
My nextcloud instance uses fail2ban and I use a >32bit strong password.
Assuming I lose my phone and my laptop and my personal computer and my nextcloud instance I would be screwed.
Since I host my own mailserver I would be able to create a new mailserver with a new password though and recover any accounts with a new email.